Sun & Moon lizard by Jose Calvo & Magaly Fuentes
In general, lizards represent good will, health, and regeneration. As a lunar creature, the lizard was believed to be tongueless and to have subsisted on dew, therefore a symbol of silence.
Lizards that warm themselves in the sun were associated with the sun and light and were sometimes viewed as seekers of spiritual enlightenment. In ancient Greece, the lizard offered itself to Apollo in order to achieve eternal light.
In Egyptian myth the lizard represented divine wisdom and good fortune and was a symbol of fecundity and devouring heat. In Roman myth the lizard that slept all winter was a symbol of death and resurrection. Since lizards shed their skin, they represented rebirth.
Australian Aboriginal myth tells of the lizard Tarrotarro, the culture hero who was the creator of the sexes and taught man the art of tattoo. In African mythology, the lizard is the embodiment of departed souls. Japanese legend tells of the lizard as a vengeful spirit with supernatural powers.
Mazadaism is the system of religion founded in Persia in the 6th century BC by Zoroaster. In the dualistic belief of two creators and two creations, the lizard is the animal created by Angra Mainyu, the personification of darkness, to destroy the Gaokerama, the Iranian plant of life.
The following is from: http://www.native-languages.org/legends-lizard.htm
Lizards play positive roles in the folklore of many Native American tribes. In Plains Indian tribes, lizards are associated with healing and survival, and also with masculinity. In some Plains tribes, a newborn boy's umbilical cord was sewn into an amulet in the shape of a lizard to ensure his health and strength. Today, many Cheyenne people still consider it bad luck to kill a lizard. In the mythology of some California Indian tribes, such as the Pomo, Lizard was one of the major figures of creation, who made humans partially in his image. In Southwestern tribes, horned lizards (sometimes called "horny-toads" in English) are considered sacred medicine animals; Gila Monster (a type of large poisonous desert lizard) features as a powerful hero in Navajo and other Southwestern legends. In other tribes, lizards are associated with protection (especially of children), prosperity, renewal, and good luck."